Clinical Trials Simulation: A Publicly Available, Grid-Enabled, GUI-Driven SAS System
نویسندگان
چکیده
A clinical trials system developed for Vertex Pharmaceuticals has become publically available on the Biopharmaceutical Network http://www.biopharmnet.com/innovation/trial_simulation/cts1.php. The system is a SAS/AF® based interface in which clinical trials’ simulation parameters can be entered; it can operate either on a SAS grid or as a stand-alone process. The statistical details are published in Westfall P.H., Tsai K., Ogenstad S., Tomoiaga A., Moseley S., and Lu Y. (2008). Clinical Trials Simulation: A Statistical Approach. Journal of Biopharmaceutical Statistics 18, 611-630. The system provides a generic template for simulations that are typically required to plan clinical trials. Realistic clinical-trial data sets are created using a unifying model that allows general correlation structures for endpoint*timepoint data and nonnormal distributions (including time-to-event), with computationally efficient algorithms. The model allows for patient dropout and noncompliance. An example is given.
منابع مشابه
Clinical Trials Simulation System
A generic template for clinical trials simulations that are typically required by statisticians is developed. Realistic clinical trials data sets are created using a unifying model that allows general correlation structures for endpoint*timepoint data and nonnormal distributions (including time-to-event), and computationally efficient algorithms are presented. The model allows for patient dropo...
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